Oxantel Disrupts Polymicrobial Biofilm Development of Periodontal Pathogens
Stuart Dashper, Neil O'Brien-Simpson, Sze Wei Liu, Rita Paolini, Helen Mitchell, Katrina Walsh, Tanya D'Cruze, Brigitte Hoffmann, Deanne Catmull, Ying Zhu, Eric Reynolds
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | AMER SOC MICROBIOLOGY | Published : 2014
Bacterial pathogens commonly associated with chronic periodontitis are the spirochete Treponema denticola and the Gram-negative, proteolytic species Porphyromonas gingivalis and Tannerella forsythia. These species rely on complex anaerobic respiration of amino acids, and the anthelmintic drug oxantel has been shown to inhibit fumarate reductase (Frd) activity in some pathogenic bacteria and inhibit P. gingivalis homotypic biofilm formation. Here, we demonstrate that oxantel inhibited P. gingivalis Frd activity with a 50% inhibitory concentration (IC50) of 2.2 μM and planktonic growth of T. forsythia with a MIC of 295 μM, but it had no effect on the growth of T. denticola. Oxantel treatment c..View full abstract
This research was partially supported by an International Association for Dental Research/Glaxo-Smith Kline Innovation in Oral Care Award.