Journal article

Birthdating of Myenteric Neuron Subtypes in the Small Intestine of the Mouse

Annette J Bergner, Lincon A Stamp, David G Gonsalvez, Margaret B Allison, David P Olson, Martin G Myers, Colin R Anderson, Heather M Young

JOURNAL OF COMPARATIVE NEUROLOGY | WILEY | Published : 2014

Abstract

There are many different types of enteric neurons. Previous studies have identified the time at which some enteric neuron subtypes are born (exit the cell cycle) in the mouse, but the birthdates of some major enteric neuron subtypes are still incompletely characterized or unknown. We combined 5-ethynynl-2'-deoxyuridine (EdU) labeling with antibody markers that identify myenteric neuron subtypes to determine when neuron subtypes are born in the mouse small intestine. We found that different neurochemical classes of enteric neuron differed in their birthdates; serotonin neurons were born first with peak cell cycle exit at E11.5, followed by neurofilament-M neurons, calcitonin gene-related pept..

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Grants

Awarded by NHMRC


Awarded by NIH


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Funding Acknowledgements

Grant sponsor: NHMRC; Grant numbers: 628349 and 1047953 (to H.M.Y.); Grant sponsor: NIH; Grant number: DK57768 (to M.G.M.).