Chronic antidepressant treatment accelerates kindling epileptogenesis in rats
Lisa Cardamone, Michael R Salzberg, Amelia S Koe, Ezgi Ozturk, Terence J O'Brien, Nigel C Jones
NEUROBIOLOGY OF DISEASE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2014
OBJECTIVES: Due to the high comorbidity of epilepsy and depression, antidepressant treatment is commonly indicated for patients with epilepsy. Studies in humans and animal models suggest that selective serotonin reuptake inhibitors (SSRIs) may reduce seizure frequency and severity, and these drugs are generally considered safe for use in epilepsy. No studies have investigated the effects of SSRIs on epileptogenesis, the neurobiological process underlying the development of the epileptic state. METHODS: The effect of continuous infusion of the SSRI, fluoxetine (10mg/kg/day sc), versus vehicle control on amygdala kindling was examined in adult male Wistar rats. Seizure threshold and kindling r..View full abstract
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Awarded by NHMRC project grant
Awarded by NHMRC Career Development Award
This study was supported by an NHMRC project grant to TJO, MS and NJ (#566843) and an NHMRC Career Development Award to NJ (#628466). The authors report no disclosures, financial or otherwise, associated with this work.