Quantification of track-weighted imaging (TWI): Characterisation of within-subject reproducibility and between-subject variability
Lisa Willats, David Raffelt, Robert E Smith, J-Donald Tournier, Alan Connelly, Fernando Calamante
NEUROIMAGE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2014
Recently several novel image contrasts derived from whole-brain fibre tracking-data (tractograms) have been introduced. The novel contrasts of these track-weighted imaging (TWI) methods may provide important information for clinical neuroscience studies. However, before they can be used reliably to generate quantitative measures, it is important to characterise their within-subject reproducibility, and between-subject variability. In this work we compute the within-subject reproducibility (intra-scan, intra-session and inter-session), and between-subject variability of TWI for a number of different TWI contrasts across multiple subjects. The results are used in simple voxel-wise power calcul..View full abstract
The authors thank Shawna Farquharson, Saba Ansari and Mary Macmillan at the Florey Institute of Neuroscience and Mental Health for their help with the acquisition of volunteer MRI data, and the subjects for kindly agreeing to take part in this study. We are grateful to the National Health and Medical Research Council (NHMRC) of Australia, the Australian Research Council (ARC) and the Victorian Government's Operational Infrastructure Support Program for their support.