Journal article

Seroprevalence of antibody to influenza A(H1N1) pdm09 attributed to vaccination or infection, before and after the second (2010) pandemic wave in Australia

Jodie McVernon, Karen Laurie, Helen Faddy, David Irving, Terry Nolan, Ian Barr, Anne Kelso



OBJECTIVES: Historical records of influenza pandemics demonstrate variability in incidence and severity between waves. The influenza A(H1N1)pdm09 pandemic was the first in which many countries implemented strain-specific vaccination to mitigate subsequent seasons. Serosurveys provide opportunity to examine the constraining influence of antibody on population disease experience. DESIGN: Changes in the proportion of adults seropositive to influenza A(H1N1)pdm09over the 2009/10 (summer) interepidemic period and 2010 (winter) influenza season were measured to determine whether there was a temporal relationship with vaccine distribution and influenza activity, respectively. SETTING: Australia. SA..

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Funding Acknowledgements

We wish to thank the donors and staff of the Australian Red Cross Blood Service (Blood Service), who have assisted in provision of specimens for testing in this protocol, as well as the staff of the WHO Collaborating Centre for Reference and Research on Influenza (WHO CC) in Melbourne, Australia. This serosurvey was funded by the Office of Health Protection, Australian Government Department of Health and Ageing and the Department of Human Services, Tasmania. We are particularly grateful to Ms Rhonda Owen, Director of the Vaccine Preventable Diseases Surveillance Section, OHP, for assistance in study conduct and reporting. The Blood Service is fully funded by the Australian Government for the provision of blood products and services to the Australian community. We thank Associate Professor Catherine Hyland and Dr Hugh Capper for their valuable contributions to study development, conduct and reporting. The Melbourne WHO Collaborating Centre for Reference and Research on Influenza is supported by the Australian Government Department of Health and Ageing. Jodie McVernon was supported by a National Health and Medical Research Council of Australia Career Development Award.