Journal article
Effect of vitamin D supplementation on antibiotic use: A randomized controlled trial
B Tran, BK Armstrong, PR Ebeling, DR English, MG Kimlin, JC Van Der Pols, A Venn, V Gebski, DC Whiteman, PM Webb, RE Neale
American Journal of Clinical Nutrition | Published : 2014
Abstract
Background: Observational data suggested that supplementation with vitamin D could reduce risk of infection, but trial data are inconsistent. Objective: We aimed to examine the effect of oral vitamin D supplementation on antibiotic use. Design: We conducted a post hoc analysis of data from pilot D-Health, which is a randomized trial carried out in a general community setting between October 2010 and February 2012. A total of 644 Australian residents aged 60-84 y were randomly assigned to receive monthly doses of a placebo (n = 214) or 30,000 (n = 215) or 60,000 (n = 215) IU oral cholecalciferol for ≤12 mo. Antibiotics prescribed during the intervention period were ascertained by linkage with..
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Awarded by National Health and Medical Research Council of Australia (NHMRC)
Funding Acknowledgements
Supported by the National Health and Medical Research Council of Australia (NHMRC) (grant 613655 and fellowships to PMW, REN, and AV), the Australian Research Council (a future fellowship to DCW), the Cancer Council Queensland (senior research fellowship to MGK), and the NHMRC Centre for Research Excellence in Sun and Health (postdoctoral research fellowship to BT). The investigational product was supplied free of charge by sanofi-aventis healthcare pty ltd trading as Sanofi Consumer Healthcare.The authors' responsibilities were as follows-BT: performed the statistical analysis and wrote the manuscript; REM: designed research, conceived the analyses, and revised the manuscript; BRA, PRE, DRE, MGK, JCvdP, AV, VG, DCW and PMW: designed the research and revised the manuscript; and all authors: contributed to the interpretation of data and approved the final version of the manuscript. The department of PRE (Northwest Academic Centre, University of Melbourne, and Western Health, Melbourne, Victoria, Australia) has received research funding and honoraria for speaker fees from sanofi-aventis healthcare. BT, BKR, DRE, MGK, JCvdP, AV, VG, DCW, PMW, and REM had no conflicts of interest. sanofi-aventis healthcare pty ltd had no role in the study other than providing the investigational product.