Journal article
The structure of integrin α1I domain in complex with a collagen-mimetic peptide
YKY Chin, SJ Headey, B Mohanty, R Patil, PA McEwan, JD Swarbrick, TD Mulhern, J Emsley, JS Simpson, MJ Scanlon
Journal of Biological Chemistry | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2013
Abstract
Background: Collagen-binding integrins bind differentially to different types of collagen. Results: The solution structure of integrin α1I domain in complex with a collagen-mimetic peptide was determined. Conclusion: Integrin α1I domain binds collagen in a distinct orientation compared with α2I, but the signal transduction mechanisms appear to be conserved. Significance: Understanding the collagen binding specificity of integrins might enable their selective modulation in disease. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
Grants
Funding Acknowledgements
This work was supported in part by a grant from the Monash-Nottingham Research Fund.