Journal article

Postprandial effects of a high salt meal on serum sodium, arterial stiffness, markers of nitric oxide production and markers of endothelial function

Kacie M Dickinson, Peter M Clifton, Louise M Burrell, P Hugh R Barrett, Jennifer B Keogh



AIM: The aim of the study was to determine if a high salt meal containing 65 mmol Na causes a rise in sodium concentrations and a reduction in plasma nitrate/nitrite concentrations (an index of nitric oxide production). Secondary aims were to determine the effects of a high salt meal on augmentation index (AIx) a measure of arterial stiffness and markers of endothelial function. METHODS AND RESULTS: In a randomised cross-over study 16 healthy normotensive adults consumed a low sodium soup containing 5 mmol Na and a high sodium soup containing 65 mmol Na. Sodium, plasma nitrate/nitrite, endothelin-1 (ET-1), C-reactive protein (CRP), vasopressin (AVP) and atrial natriuretic peptide (ANP) conce..

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University of Melbourne Researchers


Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

Supported by the Commonwealth Scientific and Industrial Research Organisation (CSIRO) and the National Health and Medical Research Council (NHMRC) grants (44102557) (1004380) (990156) (566947).KMD is supported by Postgraduate Scholarships from the Faculty of Health Science, University of Adelaide and the (CSIRO).PHRB is a NHMRC Senior Research Fellow; PMC is a NHMRC Principal Research Fellow, JBK is supported by a South Australian Cardiovascular Research Development Program Research Fellowship.