Journal article

Dengue Virus in Sub-tropical Northern and Central Viet Nam: Population Immunity and Climate Shape Patterns of Viral Invasion and Maintenance

Maia A Rabaa, Cameron P Simmons, Annette Fox, Quynh Le Mai, Thi Thu Nguyen Thuy, Yen Le Hai, Robert V Gibbons, Thanh Nguyen Xuyen, Edward C Holmes, John G Aaskov

PLOS NEGLECTED TROPICAL DISEASES | PUBLIC LIBRARY SCIENCE | Published : 2013

Abstract

Dengue virus transmission occurs in both epidemic and endemic cycles across tropical and sub-tropical regions of the world. Incidence is particularly high in much of Southeast Asia, where hyperendemic transmission plagues both urban and rural populations. However, endemicity has not been established in some areas with climates that may not support year-round viral transmission. An understanding of how dengue viruses (DENV) enter these environments and whether the viruses persist in inapparent local transmission cycles is central to understanding how dengue emerges in areas at the margins of endemic transmission. Dengue is highly endemic in tropical southern Vietnam, while increasingly large ..

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Funding Acknowledgements

Funding to MAR was provided by a National Science Foundation Graduate Research Fellowship and by the Wellcome Trust of the United Kingdom through the Vietnamese Initiative on Zoonotic InfectiONS (WT-VIZIONS). This study was supported by grants from the National Health and Medical Research Council of Australia (including an Australia Fellowship to ECH), the U.S. Global Emerging Infections Surveillance and Response System, and the National Institutes of Health (grant R01 GM087405 to ECH). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.