Journal article
Validating and improving CT ventilation imaging by correlating with ventilation 4D-PET/CT using 68Ga-labeled nanoparticles
J Kipritidis, S Siva, MS Hofman, J Callahan, RJ Hicks, PJ Keall
Medical Physics | WILEY | Published : 2014
DOI: 10.1118/1.4856055
Abstract
Purpose: CT ventilation imaging is a novel functional lung imaging modality based on deformable image registration. The authors present the first validation study of CT ventilation using positron emission tomography with 68Ga-labeled nanoparticles (PET-Galligas). The authors quantify this agreement for different CT ventilation metrics and PET reconstruction parameters. Methods: PET-Galligas ventilation scans were acquired for 12 lung cancer patients using a four-dimensional (4D) PET/CT scanner. CT ventilation images were then produced by applying B-spline deformable image registration between the respiratory correlated phases of the 4D-CT. The authors test four ventilation metrics, two exist..
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Funding Acknowledgements
The authors would like to thank Professor Rebecca Fahrig (Stanford University, CA, USA), Dr. Tokihiro Yamamoto (University of California-Davis, CA, USA), and Dr. Nicholas Hardcastle (Peter MacCallum Cancer Centre, Melbourne VIC, Australia) for providing valuable guidance on deformable registration and data analysis. The authors would also like to thank Mr. Peter Eu (Peter MacCallum Cancer Centre, Melbourne VIC, Australia) for Galligas production. This work is supported by an NHMRC Australia Fellowship.