Journal article
Human amniotic epithelial cells suppress relapse of corticosteroid-remitted experimental autoimmune disease
Yu-Han Liu, James Chan, Vijesh Vaghjiani, Padma Murthi, Ursula Manuelpillai, Ban-Hock Toh
CYTOTHERAPY | ELSEVIER SCI LTD | Published : 2014
Abstract
BACKGROUND AIMS: Multiple sclerosis (MS) is considered to be a T-cell-mediated disease. Although MS remits with corticosteroid treatment, the disease relapses on discontinuation of therapy. Human amniotic epithelial cells (hAEC) from the placenta are readily accessible in large quantities and have anti-inflammatory properties. Previously we reported that hAEC given near disease onset ameliorated clinical signs and decreased myelin oligodendrocyte glycoprotein (MOG)-specific immune responses in MOG-induced experimental autoimmune encephalomyelitis (EAE), an experimental MS model. METHODS: To examine the therapeutic effect of hAEC in a clinically relevant setting, we first treated MOG peptide-..
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Awarded by Australian National Health & Medical Research Council
Funding Acknowledgements
This work was funded by the Australian National Health & Medical Research Council (program grant No. 436634 for Y.H.L., J.C. and B.H.T., project grant No. 509140 for P.M. and No. 606473 for V.V. and U.M.). V.V. and U.M. are also supported by the Victorian Government's Operational Infrastructure Support Program.