Journal article
Impact of ethnicity, geography, and disease on the microbiota in health and inflammatory bowel disease
L Prideaux, S Kang, J Wagner, M Buckley, JE Mahar, P De Cruz, Z Wen, L Chen, B Xia, DR Van Langenberg, T Lockett, SC Ng, JJY Sung, P Desmond, C McSweeney, M Morrison, CD Kirkwood, MA Kamm
Inflammatory Bowel Diseases | Published : 2013
Abstract
Background: The gut microbiota is central to health and disorders such as inflammatory bowel disease. Differences in microbiota related to geography and ethnicity may hold the key to recent changes in the incidence of microbiota-related disorders. Methods: Gut mucosal microbiota was analyzed in 190 samples from 87 Caucasian and Chinese subjects, from Australia and Hong Kong, comprising 22 patients with Crohn's disease, 30 patients with ulcerative colitis, 29 healthy controls, and 6 healthy relatives of patients with Crohn's disease. Bacterial 16S rRNA microarray and 454 pyrosequencing were performed. Results: The microbiota was diverse in health, regardless of ethnicity or geography (operati..
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Funding Acknowledgements
Supported by the Broad Foundation, the Murdoch Childrens Research Institution, and the Victorian Government's Operational Infrastructure Support Program. C. D. Kirkwood and M. A. Kamm were supported by Research Fellowships from the National Health and Medical Research Council (NHMRC) of Australia, L. Prideaux by an Australian Postgraduate Award, and M. A. Kamm by the St Vincent's Research Endowment Fund. Financial support from CSIRO's Transformational Biology Capability Platform grants scheme and the Preventative Health National Research Flagship Program is gratefully acknowledged.