Journal article

Spike-and-wave discharge mediated reduction in hippocampal HCN1 channel function associates with learning deficits in a genetic mouse model of epilepsy

A Marie Phillips, Taehwan Kim, Ernesto Vargas, Steven Petrou, Christopher A Reid

NEUROBIOLOGY OF DISEASE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2014

Abstract

The GABAAγ2(R43Q) mouse is an established model of absence epilepsy displaying spontaneous spike-and-wave discharges (SWD) and associated behavioral arrest. Absence epilepsy typically results from cortico-thalamic networks. Nevertheless, there is increasing evidence for changes in hippocampal metabolism and electrical behavior, consistent with a link between absence seizures and hippocampus-related co-morbidities. Hyperpolarization-activated-cyclic-nucleotide-gated (HCN) channels are known to be transcriptionally regulated in a number of seizure models. Here we investigate the expression and function of these channels in the hippocampus of the genetic epilepsy model. A reduction in HCN1, but..

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Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by Australian Future Fellowship, Australian Research Council


Awarded by NHMRC


Funding Acknowledgements

This study was supported by the National Health and Medical Research Council of Australia (APP 1009142). CAR was also supported by an Australian Future Fellowship, Australian Research Council (#FT0990628). SP was supported by a NHMRC fellowship (1005050). Florey Institute of Neuroscience and Mental Health is supported by the Victorian State Government Infrastructure Funds. We wish to acknowledge Mr. Travis Featherby for the help with completing the behavioral testing.