Reduced parahippocampal cortical thickness in subjects at ultra-high risk for psychosis

S Tognin; A Riecher-Roessler; EM Meisenzahl; SJ Wood; C Hutton; SJ Borgwardt; N Koutsouleris; AR Yung; P Allen; LJ Phillips; PD McGorry; I Valli; D Velakoulis; B Nelson; J Woolley; C Pantelis; P McGuire; A Mechelli

Journal article

Reduced parahippocampal cortical thickness in subjects at ultra-high risk for psychosis

S Tognin, A Riecher-Roessler, EM Meisenzahl, SJ Wood, C Hutton, SJ Borgwardt, N Koutsouleris, AR Yung, P Allen, LJ Phillips, PD McGorry, I Valli, D Velakoulis, B Nelson, J Woolley, C Pantelis, P McGuire, A Mechelli

PSYCHOLOGICAL MEDICINE | CAMBRIDGE UNIV PRESS | Published : 2014

DOI: 10.1017/S0033291713000998

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Abstract

BACKGROUND: Grey matter volume and cortical thickness represent two complementary aspects of brain structure. Several studies have described reductions in grey matter volume in people at ultra-high risk (UHR) of psychosis; however, little is known about cortical thickness in this group. The aim of the present study was to investigate cortical thickness alterations in UHR subjects and compare individuals who subsequently did and did not develop psychosis. METHOD: We examined magnetic resonance imaging data collected at four different scanning sites. The UHR subjects were followed up for at least 2 years. Subsequent to scanning, 50 UHR subjects developed psychosis and 117 did not. Cortical thi..

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University of Melbourne Researchers

Christos Pantelis Author Psychiatry

Stephen Wood Author Centre for Youth Mental Health

Patrick McGorry Author Centre for Youth Mental Health

Barnaby Nelson Author Centre for Youth Mental Health

Lisa Phillips Author Melbourne School of Psychological Sciences

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Grants

Awarded by National Health and Medical Research Council of Australia

Awarded by National Health and Medical Research Council Clinical Career Developmental Award

Awarded by National Health and Medical Research Council Senior Principal Research Fellowship

Awarded by National Health and Medical Research Council Senior Research Fellowship

Awarded by Wellcome Trust

Awarded by Medical Research Council

Awarded by National Institute for Health Research

Funding Acknowledgements

This work was supported by the National Alliance for Research on Schizophrenia and Depression Independent Investigator Award to A.M.; the National Health and Medical Research Council of Australia (grant no. 970391, 981112, 145737, 145627, 350241, 566529); the National Health and Medical Research Council Clinical Career Developmental Award (grant no. 359223 to S.W.); the National Alliance for Research on Schizophrenia and Depression Young Investigator Award to S.W.; the National Health and Medical Research Council Senior Principal Research Fellowship (grant no. 628386 to C.P.); the National Alliance for Research on Schizophrenia and Depression Distinguished Investigator Award to C.P.; the National Health and Medical Research Council Senior Research Fellowship (grant no. 566593 to A.Y.) and the Wellcome Trust (grant no. 091593/Z/10/Z to C.H.).