Journal article

The contribution of twins to the study of cognitive ageing and dementia: The Older Australian Twins Study

Perminder S Sachdev, Teresa Lee, Wei Wen, David Ames, Amir H Batouli, Jocelyn Bowden, Henry Brodaty, Elizabeth Chong, John Crawford, Kristan Kang, Karen Mather, Andrea Lammel, Melissa J Slavin, Anbupalam Thalamuthu, Julian Trollor, Margie J Wright

INTERNATIONAL REVIEW OF PSYCHIATRY | TAYLOR & FRANCIS LTD | Published : 2013

Abstract

The Older Australian Twins Study (OATS) is a major longitudinal study of twins, aged ≥ 65 years, to investigate genetic and environmental factors and their interactions in healthy brain ageing and neurocognitive disorders. The study collects psychiatric, neuropsychological, cardiovascular, metabolic, biochemical, neuroimaging, genomic and proteomic data, with two-yearly assessments, and is currently in its third wave. The initial cohort comprises 623 individuals (161 monozygotic and 124 dizygotic twin pairs; 1 MZ triplets; 27 single twins and 23 non-twin siblings), of whom 426 have had wave 2 assessment. A number of salient findings have emerged thus far which assist in the understanding of ..

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University of Melbourne Researchers