Journal article

Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity

Romain Bedel, Richard Berry, Thierry Mallevaey, Jennifer L Matsuda, Jingjing Zhang, Dale I Godfrey, Jamie Rossjohn, John W Kappler, Philippa Marrack, Laurent Gapin

Proceedings of the National Academy of Sciences | NATL ACAD SCIENCES | Published : 2014


Awarded by National Institutes of Health

Awarded by Cancer Center Support Grant

Funding Acknowledgements

We thank members of the L. G. laboratory, John Cambier, and Leonard Dragone for thoughtful discussion and critical comments on the manuscript; Derek Sant'Angelo for the antipromyelocytic zinc finger transcription factor mAb used in preliminary experiments; the National Jewish Health flow cytometry facility, the Mucosal and Vaccine Research Colorado Flow Core, and the University of Colorado flow cytometry shared resource facility for assistance with cell sorting; the Center for Genes, Environment, and Health at National Jewish Health for sequencing and the National Institutes of Health core facility for CD1d tetramers. This work was supported by National Institutes of Health Grants AI18785 and AI22295 (to P. M. and J.W.K.), and AI092108 (to L. G.); The Cancer Center Support Grant P30CA046934; the Howard Hughes Medical Institute (P. M. and J.W. K.); the National Health and Medical Research Council (NHMRC) Australia Fellowship (to J.R.); the NHMRC Senior Principal Research Fellowship (to D. I. G.); a NHMRC Peter Doherty fellowship (to Richard Berry); NHMRC Program grants (to D. I. G.); and a Cancer Council of Victoria grant (to J.R. and D.I.G.).