Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis
Toru Okamoto, Leigh Coultas, Donald Metcalf, Mark F van Delft, Stefan P Glaser, Megumi Takiguchi, Andreas Strasser, Philippe Bouillet, Jerry M Adams, David CS Huang
Proceedings of the National Academy of Sciences of the United States of America | NATL ACAD SCIENCES | Published : 2014
Awarded by Australian National Health and Medical Research Council
We thank P. Colman, S. Cory, P. Czabotar, R. Dickins, P. Kelly, S. L. Khaw, K. Mason, D. Segal, M. Okada, and C. Oneyama for discussions and suggestions; C. Borner, B. Kile, D. Loh, the late S. Korsmeyer, N. Motoyama, and C. Thompson for gifts of reagents and mouse strains; AbbVie for ABT-737; J. Corbin, L. Di Rago, A. Georgiou, H. Ierino, A. Mifsud, A. Srikumar, and E. Trounson for technical assistance; T. Camillieri, H. Donatucci, K. McKenzie, G. Siciliano, E. Sutherland, and K. Trueman for animal husbandry; E. Tsui for histology; and K. Aumann for editing. This work is supported by scholarships, fellowships, and grants from the University of Melbourne (International Research Scholarship to M.F.v.D.), the Australian Research Council (Discovery Early Career Researcher Award to T.O. and Future Fellowship to L.C.), the Australian National Health and Medical Research Council (Career Development Award to P.B.; Research Fellowships to A.S., J.M.A., and D.C.S.H.; Australia Fellowship to A.S.; Project Grants to L.C. and D.C.S.H.; Program Grants 461219, 461221, and 1016701; and Independent Research Institutes Infrastructure Support Scheme Grant 361646), the Cancer Council Victoria (fellowships to M.F.v.D. and D.M.; grants-in-aid to A.S. and D.C.S.H.), the Leukemia and Lymphoma Society (Specialized Centers of Research Grants), the Australian Cancer Research Foundation, and a Victorian State Government Operational Infrastructure Support Grant.