Journal article
Association of the hepatocyte growth factor gene with Keratoconus in an Australian population
S Sahebjada, M Schache, AJ Richardson, G Snibson, M Daniell, PN Baird
Plos One | Published : 2014
Open access
Abstract
Purpose: A previous study has indicated suggestive association of the hepatocyte growth factor (HGF) gene with Keratoconus. We wished to assess this association in an independent Caucasian cohort as well as assess its association with corneal curvature. Participants: Keratoconus patients were recruited from private and public clinics in Melbourne, Australia. Non-keratoconic individuals were identified from the Genes in Myopia (GEM) study from Australia. A total of 830 individuals were used for the analysis including 157 keratoconic and 673 non keratoconic subjects. Methods: Tag single nucleotide polymorphisms (tSNPs) were chosen to encompass the hepatocyte growth factor gene as well as 2 kb ..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This project was funded by the National Health and Medical Research Council (NHMRC) Clinical Research Excellence grant 529923 - Translational Clinical Research in Major Eye Diseases, NHMRC Senior Research Fellowship 1028444 (PNB) and the Angior Family Foundation. The Centre for Eye Research Australia (CERA) receives Operational Infrastructure Support from the Victorian Government. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.