Risedronate Slows or Partly Reverses Cortical and Trabecular Microarchitectural Deterioration in Postmenopausal Women
Yohann Bala, Roland Chapurlat, Angela M Cheung, Dieter Felsenberg, Michel LaRoche, Edward Morris, Jonathan Reeve, Thierry Thomas, Jose Zanchetta, Oliver Bock, Ali Ghasem-Zadeh, Roger Martin Zebaze Djoumessi, Ego Seeman, Rene Rizzoli
JOURNAL OF BONE AND MINERAL RESEARCH | WILEY | Published : 2014
During early menopause, steady-state bone remodeling is perturbed; the number of basic multicellular units (BMUs) excavating cavities upon the endosteal surface exceeds the number (generated before menopause) concurrently refilling. Later in menopause, steady-state is restored; the many BMUs generated in early menopause refill as similarly large numbers of BMUs concurrently excavate new cavities. We hypothesized that risedronate reduces the number of cavities excavated. However, in younger postmenopausal women, the fewer cavities excavated will still exceed the fewer BMUs now refilling, so net porosity increases, but less than in controls. In older postmenopausal women, the fewer cavities ex..View full abstract
The study was funded by Warner Chilcott (US) LLC and Sanofi. The funding sources participated in the design, conduct, and analysis of the study. We thank Miriam Annett (Warner Chilcott) and Dietrich Wenderoth (Warner Chilcott) for statistical and technical support. The authors are responsible for the content, editorial decisions, and opinions expressed in the article.