Journal article
MR-less surface-based amyloid assessment based on11C PiB PET
L Zhou, O Salvado, V Dore, P Bourgeat, P Raniga, SL Macaulay, D Ames, CL Masters, KA Ellis, VL Villemagne, CC Rowe, J Fripp
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2014
Open access
Abstract
Background: β-amyloid (Aβ) plaques in brain's grey matter (GM) are one of the pathological hallmarks of Alzheimer's disease (AD), and can be imaged in vivo using Positron Emission Tomography (PET) with 11C or 18F radiotracers. Estimating Aβ burden in cortical GM has been shown to improve diagnosis and monitoring of AD. However, lacking structural information in PET images requires such assessments to be performed with anatomical MRI scans, which may not be available at different clinical settings or being contraindicated for particular reasons. This study aimed to develop an MR-less Aβ imaging quantification method that requires only PET images for reliable Aβ burden estimations. Materials a..
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Funding Acknowledgements
Core funding for the AIBL study was provided by the CSIRO (http://www.csiro.au/) Flagship Collaboration Fund and the Science and Industry Endowment Fund (SIEF http://www.sief.org.au/) in partnership with Edith Cowan University (https://www.ecu.edu.au/), Florey neuro-sciences and Mental Health Research institutes (http://www.florey.edu.au/), Alzheimer's Australia (http://www.fightdementia.org.au/), National Age-ing Research Institute (http://www.mednwh.unimelb.edu.au/), Austin Health (http://www.austin.org.au/), CogState Ltd. (http://cogstate.com/), Hollywood Private Hospital (http://www.hollywood.ramsayhealth.com.au/), Sir Charles Gardner Hospital (http://www.scgh.health.wa.gov.au/). The AIBL study also receives funding from the National Health and Medical Research Council (http://www.nhmrc.gov.au/), the Dementia Collaborative Research Centers program (http://www.fightdementia.org.au/victoria/dementia-collaborative-research-centres-1.aspx), The McCusker Alzheimer's Research Foundation (http://alzheimers.com.au/) and Operational Infrastructure Support from the Government of Victoria (http://www.vic.gov.au/), Australia. Pfizer International (http://www.pfizer.com.au/default.aspx) has contributed financial support to AIBL to assist with analysis of blood samples and to further the AIBL research program. The funders had no role in study design and data analysis, decision to publish, or preparation of this manuscript.