Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL

James M Murphy; Isabelle S Lucet; Joanne M Hildebrand; Maria C Tanzer; Samuel N Young; Pooja Sharma; Guillaume Lessene; Warren S Alexander; Jeffrey J Babon; John Silke; Peter E Czabotar

Journal article

Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL

James M Murphy, Isabelle S Lucet, Joanne M Hildebrand, Maria C Tanzer, Samuel N Young, Pooja Sharma, Guillaume Lessene, Warren S Alexander, Jeffrey J Babon, John Silke, Peter E Czabotar

Biochemical Journal | PORTLAND PRESS LTD | Published : 2014

DOI: 10.1042/BJ20131270

University of Melbourne Researchers

Peter Czabotar Author Medical Biology (W.E.H.I.)

Guillaume Lessene Author Medical Biology (W.E.H.I.)

James Murphy Author Medical Biology (W.E.H.I.)

John Silke Author Medical Biology (W.E.H.I.)

Joanne Hildebrand Author Medical Biology (W.E.H.I.)

Grants

Awarded by NHMRC (National Health and Medical Research Council)

Awarded by Australian Research Council

Awarded by NHMRC IRIISS (Independent Medical Research Institutes Infrastructure Support Scheme)

Funding Acknowledgements

This work was supported by the NHMRC (National Health and Medical Research Council) [grant numbers 637342, 1016647 and 1046984] and fellowships to J.M.H., W.S.A. and J.S.; Australian Research Council fellowships [FT100100100, FT110100169 and FT0992105] to J.M.M., J.J.B. and P.E.C.; a Victorian International Research Scholarship to M.C.T.; with additional support from the Victorian State Government Operational Infrastructure Support and NHMRC IRIISS (Independent Medical Research Institutes Infrastructure Support Scheme) [grant 361646]. J.S. is a member of the Scientific Advisory Board of TetraLogic Pharmaceuticals.