Journal article

Detection of HCV-Specific IFN-gamma Responses in HCV Antibody and HCV RNA Negative Injecting Drug Users

Jacqueline K Flynn, Rachel Sacks-Davis, Peter Higgs, Campbell Aitken, Sarah Moneer, Vijay Suppiah, Lilly Tracy, Rosemary Ffrench, Scott Bowden, Heidi Drummer, Jacob George, Mandvi Bharadwaj, Margaret Hellard



BACKGROUND: Detectable HCV-specific cellular immune responses in HCV antibody and RNA negative people who inject drugs (PWID) raise the question of whether some are resistant to HCV infection. Immune responses from people who have been exposed to hepatitis C virus (HCV) and remain anti-HCV negative are of interest for HCV vaccine development; however, limited research addresses this area. OBJECTIVES: In a cohort of HCV antibody and RNA negative PWID, we assessed whether the presence of HCV-specific IFN-γ responses or genetic associations provide any evidence of protection from HCV infection. PATIENTS AND METHODS: One hundred and ninety-eight participants were examined longitudinally for clin..

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Awarded by Australia's National Health and Medical Research Council

Funding Acknowledgements

We gratefully acknowledge funding for our research from Australia's National Health and Medical Research Council (project grant 331312) and the Victorian Department of Human Services (public health research grant, 2008-09) and the Burnet Institute. The authors gratefully acknowledge the contribution to this work of the Victorian Operational Infrastructure Support Program, received by the Burnet Institute. The National Drug Research Institute at Curtin University is supported by funding from the Australian Government under the Substance Misuse Prevention and Service Improvement Grants Fund. Rachel Sacks-Davis is supported by an NHMRC Public Health Postgraduate Research Scholarship, Peter Higgs is supported by a Curtin University Research Fellowship, Rose French is supported by an NHMRC Industry Fellowship, Heidi Drummer is supported by an NHMRC RD Wright Career Development Award, Jacob George is supported by the NHMRC and the Robert W. Storr Bequest to the Medical Foundation of the University of Sydney and Margaret Hellard is supported by an NHMRC Senior Research Fellowship.