Journal article
Proximal and distal gastro-oesophageal reflux in chronic obstructive pulmonary disease and bronchiectasis
AL Lee, BM Button, L Denehy, SJ Roberts, TL Bamford, SJ Ellis, FT Mu, RG Heine, RG Stirling, JW Wilson
Respirology | Published : 2014
DOI: 10.1111/resp.12182
Abstract
Background and objective The aims of this observational study were (i) to examine the prevalence of symptomatic and clinically silent proximal and distal gastro-oesophageal reflux (GOR) in adults with chronic obstructive pulmonary disease (COPD) or bronchiectasis, (ii) the presence of gastric aspiration, and (iii) to explore the possible clinical significance of this comorbidity in these conditions. Methods Twenty-seven participants with COPD, 27 with bronchiectasis and 17 control subjects completed reflux symptom evaluation and dual-channel 24 h oesophageal pH monitoring. In those with lung disease, pepsin levels in sputum samples were measured using enzyme-linked immunosorbent assay, with ..
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Funding Acknowledgements
The authors thank all participants in the study, as well as Ivana Gloglowski (Monash University) for her excellent laboratory assistance, Dr Nicole Mifsud (Monash University) for her advice and the staff of the Respiratory Laboratory (Alfred Health) for completing the spirometry measures. This study was supported by the Physiotherapy Research Foundation, The University of Melbourne, Monash University, and the National Health and Medical Research Council.