Journal article
Novel implications of Lingo-1 and its signaling partners in schizophrenia
F Fernandez-Enright, JL Andrews, KA Newell, C Pantelis, XF Huang
Translational Psychiatry | Published : 2014
DOI: 10.1038/tp.2013.121
Abstract
Myelination and neurite outgrowth both occur during brain development, and their disturbance has been previously been implicated in the pathophysiology of schizophrenia. Leucine-rich repeat and immunoglobulin domain-containing protein (Lingo-1) is a potent negative regulator of axonal myelination and neurite extension. As co-factors of Lingo-1 signaling (Nogo receptor (NgR), With No Lysine (K) (WNK1) and Myelin transcription factor 1 (Myt1)) have been implicated in the genetics of schizophrenia, we explored for the first time the role of Lingo-1 signaling pathways in this disorder. Lingo-1 protein, together with its co-receptor and co-factor proteins NgR, tumor necrosis factor (TNF) receptor..
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Grants
Awarded by National Institute on Alcohol Abuse and Alcoholism
Funding Acknowledgements
This work was supported by an Illawarra Health and Medical Research Institute Program Grant and by the Schizophrenia Research Institute, using infrastructure funding from the NSW Ministry of Health. Tissues were received from the NSW Tissue Resource Centre at the University of Sydney and the Sydney Brain Bank, which is supported by the National Health and Medical Research Council of Australia, The University of NSW, Neuroscience Research Australia, the Schizophrenia Research Institute and the National Institute of Alcohol Abuse and Alcoholism (NIH (NIAAA) R24AA012725). Tissues were prepared by the Schizophrenia Research Laboratory, a joint initiative of the Schizophrenia Research Institute, University of NSW, Neuroscience Research Australia and the Macquarie Group Foundation. CP was supported by a National Health and Medical Research Council (NHMRC) Senior Principal Research Fellowship (ID: 628386) and National Alliance for Research on Schizophrenia and Depression (NARSAD) Distinguished Investigator Award. FF-E designed and supervised the experiments and wrote the manuscript; JLA performed the experiments and wrote the manuscript; KAN participated in writing the manuscript and performing the experiments; CP and XFH suggested changes to the final version of the manuscript utilizing their knowledge of schizophrenia. JLA is supported by an Ian Scott Scholarship from Australian Rotary Health.