Serum selenium status in Graves' disease with and without orbitopathy: A case-control study

Abstract

Objective Selenium is effective in improving quality of life and reducing the progression of active Graves' orbitopathy. The effect of correcting relative selenium deficiency on improving Graves' orbitopathy is unknown, as baseline selenium levels have not previously been measured. The study aims to determine whether serum selenium levels are reduced in patients with Graves' disease with orbitopathy (GO) compared with without orbitopathy (GD). Design A prospective, case-control study performed between 2009 and 2012 at endocrine and ophthalmology clinics in Australia. Patients A total of 198 patients with Graves' disease participated in the study: 101 with Graves' orbitopathy and 97 without G..