Targeting the nucleolus for cancer intervention
Jaclyn E Quin, Jennifer R Devlin, Donald Cameron, Kate M Hannan, Richard B Pearson, Ross D Hannan
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | ELSEVIER | Published : 2014
The contribution of the nucleolus to cancer is well established with respect to its traditional role in facilitating ribosome biogenesis and proliferative capacity. More contemporary studies however, infer that nucleoli contribute a much broader role in malignant transformation. Specifically, extra-ribosomal functions of the nucleolus position it as a central integrator of cellular proliferation and stress signaling, and are emerging as important mechanisms for modulating how oncogenes and tumor suppressors operate in normal and malignant cells. The dependence of certain tumor cells to co-opt nucleolar processes to maintain their cancer phenotypes has now clearly been demonstrated by the app..View full abstract
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Awarded by NHMRC of Australia
Awarded by RBP
This work was supported by grants from the NHMRC of Australia to RDH (#166908 & #251688) & RBP (#I043884, #509087 & #400116), Prostate Cancer Foundation of Australia to RDH & RBP, and Leukaemia Foundation of Australia to RDH. Researchers were supported by NHMRC (Research Fellowships to RDH & RBP), Australian Federal Government (Australian Postgraduate Award to JEQ) and Leukaemia Foundation of Australia (Postgraduate Research Award to JRD).