Journal article
Percutaneous image-guided biopsy of prostate cancer metastases yields samples suitable for genomics and personalised oncology
MKH Hong, N Sapre, PM Phal, G MacIntyre, X Chin, JS Pedersen, A Ryan, M Kerger, AJ Costello, NM Corcoran, CM Hovens
Clinical and Experimental Metastasis | SPRINGER | Published : 2014
Abstract
Personalised oncology through mutational profiling of cancers requires the procurement of fresh frozen tumour samples for genomics applications. While primary cancers are often surgically excised and therefore yield such tissue, metastases in the setting of a known cancer diagnosis are not routinely sampled prior to systemic therapy. Our study aimed to determine the suitability of extracted nucleic acids for genomics applications using distant metastatic prostate cancer samples obtained via percutaneous or surgical biopsy. Patients with metastatic prostate cancer were recruited for image-guided biopsy of metastases. Patients undergoing surgical procedures for the complications of metastases ..
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Funding Acknowledgements
MKHH has been supported by scholarships from the Royal Australasian College of Surgeons, the National Health and Medical Research Council, Australia, and the Melville Hughes Scholarship, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne. GM is supported by NICTA. NICTA is funded by the Australian Government as represented by the Department of Broadband, Communications and the Digital Economy and the Australian Research Council through the ICT Centre of Excellence program. MK is supported by the Carlo Vaccari Scholarship. We gratefully acknowledge the Australian Genome Research Facility for providing genomics services, Associate Professor Kate Drummond for her assistance in procurement of some samples, and also the men who so kindly donated their metastatic tissues.