Journal article
Human papillomavirus (HPV) genotypes in an Australian sample of anal cancers
RJ Hillman, SM Garland, MPW Gunathilake, M Stevens, N Kumaradevan, C Lemech, RL Ward, A Meagher, L McHugh, F Jin, S Carroll, D Goldstein, AE Grulich, SN Tabrizi
International Journal of Cancer | Published : 2014
DOI: 10.1002/ijc.28730
Abstract
Human papillomavirus (HPV) causes most cases of anal cancers. In this study, we analyzed biopsy material from 112 patients with anal cancers in Australia for the presence of HPV DNA by the INNO LiPA HPV genotyping assay. There were 82% (92) males and 18% (20) females. The mean age at diagnosis was significantly (p = 0.006) younger for males (52.5 years) than females (66 years). HIV-infected males were diagnosed at a much earlier mean age (48.2 years) than HIV negative (56.3 years) males (p = 0.05). HPV DNA was detected in 96.4% (108) of cases. HPV type 16 was the commonest, at 75% (81) of samples and being the sole genotype detected in 61% (66). Overall, 79% (85) of cases had at least one ge..
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Funding Acknowledgements
RJH received travel support and grants from CSL and Merck-distributor and manufacturer of the qHPV vaccine. SMG received advisory board fees and grant support from CSL and GlaxoSmithKline, lecturer fees from Merck, GSK and Sanofi Pasteur, received funding through her institution to conduct HPV vaccine studies for MSD and GSK and she is a member of the Merck Global Advisory Board and scientific advisory committee for HPV. AEG received honoraria, travel and research funding from Merck. MPWG, CL, NK, RLW, LM, FJ, SC, DG and SNT declare that they have no conflicts of interest.