Journal article

Development of temperamental effortful control mediates the relationship between maturation of the prefrontal cortex and psychopathology during adolescence: A 4-year longitudinal study

Nandita Vijayakumar, Sarah Whittle, Meg Dennison, Murat Yuecel, Julian Simmons, Nicholas B Allen



This study investigated the relationship between the development of effortful control (EC), a temperamental measure of self-regulation, and concurrent development of three regions of the prefrontal cortex (anterior cingulate cortex, ACC; dorsolateral prefrontal cortex, dlPFC; ventrolateral prefrontal cortex, vlPFC) between early- and mid-adolescence. It also examined whether development of EC mediated the relationship between cortical maturation and emotional and behavioral symptoms. Ninety-two adolescents underwent baseline assessments when they were approximately 12 years old and follow-up assessments approximately 4 years later. At each assessment, participants had MRI scans and completed..

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Awarded by National Health and Medical Research Council (NHMRC; Australia)

Awarded by Australian Research Council

Awarded by NHMRC Career Development Fellowship

Awarded by NHMRC Fellowship

Funding Acknowledgements

This research was supported by grants from the Colonial Foundation, the National Health and Medical Research Council (NHMRC; Australia; Program Grant 350241) and the Australian Research Council (ARC; Discovery Grant DP0878136). Ms. Vijayakumar is supported by a Melbourne International Research Scholarship. Dr. Whittle is supported by a NHMRC Career Development Fellowship (ID: 1007716). Ms Dennison is supported by an Australian Postgraduate Award. Prof. Yucel is supported by an NHMRC Fellowship (ID: 1021973).