Lipidated promiscuous peptide augments the expression of MHC-II molecules on dendritic cells and activates T cells
Uthaman Gowthaman, Pradeep K Rai, Weiguang Zeng, David C Jackson, Javed N Agrewala
INDIAN JOURNAL OF MEDICAL RESEARCH | INDIAN COUNCIL MEDICAL RES | Published : 2013
BACKGROUND & OBJECTIVES: In spite of the fact that BCG is the most widely used vaccine, tuberculosis (TB) continues to be a major killer disease in TB-endemic regions. Recently, many emerging evidences from the published literature indicate the role of environmental mycobacteria in blocking the processing and presentation of BCG antigens and thereby impairing with suboptimal generation of protective T cells. To surmount this problem associated with BCG, we constructed a novel lipopeptide (L91) by conjugating a promiscuous peptide consisting of CD4 + T-helper epitope of sequence of 91-110 of 16 kDa antigen of Mycobacterium tuberculosis to Pam2Cys, an agonist of Toll-like receptor-2. METHODS: ..View full abstract
Authors acknowledge the CSIR, DBT and ICMR, India for financial support. The first two authors (UG and PKR) were recipients of DBT and CSIR fellowships, respectively. D.C. Jackson and W. Zeng are supported by the National Health and Medical Research Council of Australia.