Journal article

Lipidated promiscuous peptide augments the expression of MHC-II molecules on dendritic cells and activates T cells

Uthaman Gowthaman, Pradeep K Rai, Weiguang Zeng, David C Jackson, Javed N Agrewala

INDIAN JOURNAL OF MEDICAL RESEARCH | INDIAN COUNCIL MEDICAL RES | Published : 2013

Abstract

BACKGROUND & OBJECTIVES: In spite of the fact that BCG is the most widely used vaccine, tuberculosis (TB) continues to be a major killer disease in TB-endemic regions. Recently, many emerging evidences from the published literature indicate the role of environmental mycobacteria in blocking the processing and presentation of BCG antigens and thereby impairing with suboptimal generation of protective T cells. To surmount this problem associated with BCG, we constructed a novel lipopeptide (L91) by conjugating a promiscuous peptide consisting of CD4 + T-helper epitope of sequence of 91-110 of 16 kDa antigen of Mycobacterium tuberculosis to Pam2Cys, an agonist of Toll-like receptor-2. METHODS: ..

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