Journal article
Reticular pseudodrusen: A risk factor for geographic atrophy in fellow eyes of individuals with unilateral choroidal neovascularization
RP Finger, Z Wu, CD Luu, F Kearney, LN Ayton, LM Lucci, WC Hubbard, JL Hageman, GS Hageman, RH Guymer
Ophthalmology | Published : 2014
Abstract
Purpose To determine whether reticular pseudodrusen (RPD) confer an increased risk of progression to late-stage age-related macular degeneration (AMD) in fellow eyes of those recently diagnosed with unilateral choroidal neovascularization (CNV). Design Retrospective study. Participants Two hundred consecutive participants with CNV secondary to AMD in 1 eye and no signs of late-stage AMD in the fellow eye. Methods Clinical examination and comprehensive retinal imaging, including spectral-domain optical coherence tomography, near-infrared reflectance (NIR), and color fundus photography, at baseline and every follow-up visit. Main Outcome Measures Incidence of geographic atrophy (GA) and CNV in..
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Awarded by National Eye Institute
Funding Acknowledgements
Supported by the German Research Council (grant no.: DFG FI 1540/5-1 [R.P.F.]); the Perpetual Foundation Australia; Novartis Australia; Bayer Australia; the National Health and Medical Research Council Australia (grant nos.: 590205 and 1008979; practitioner fellowship no.: 529905 [R.H.G.]; and Centre for Clinical Research Excellence grant no.: 529923); the Macular Degeneration Foundation Australia (R.H.G. and G.S.H.); the BrightFocus Foundation, Clarksburg, MD; the National Institutes of Health, Bethesda, Maryland (grant no.: R24 EY017404 [G.S.H.]); the American Macular Degeneration Foundation, Inc, Northampton, MA; (G.S.H.); the Helen K. and Arthur E. Johnson Foundation, Denver, CO; (G.S.H.); the Willard L. Eccles Charitable Foundation, Salt Lake City, UT (G.S.H.); Sylvia E. Prahl-Brodbeck (G.S.H.); Sharon E. Steele-McGee; and Research to Prevent Blindness, Inc., New York, New York (unrestricted grant to the University of Utah John A. Moran Eye Center and the Department of Ophthalmology and Visual Sciences). The Centre for Eye Research Australia receives operational infrastructure support from the Victorian Government. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.