Journal article

Susceptibility to Acute Rheumatic Fever Based on Differential Expression of Genes Involved in Cytotoxicity, Chemotaxis, and Apoptosis

Penelope A Bryant, Gordon K Smyth, Travis Gooding, Alicia Oshlack, Zinta Harrington, Bart Currie, Jonathan R Carapetis, Roy Robins-Browne, Nigel Curtis



It is unknown why only some individuals are susceptible to acute rheumatic fever (ARF). We investigated whether there are differences in the immune response, detectable by gene expression, between individuals who are susceptible to ARF and those who are not. Peripheral blood mononuclear cells (PBMCs) from 15 ARF-susceptible and 10 nonsusceptible (control) adults were stimulated with rheumatogenic (Rh+) group A streptococci (GAS) or nonrheumatogenic (Rh-) GAS. RNA from stimulated PBMCs from each subject was cohybridized with RNA from unstimulated PBMCs on oligonucleotide arrays to compare gene expression. Thirty-four genes were significantly differentially expressed between ARF-susceptible an..

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Awarded by Australian National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

This work was supported by a grant from the National Heart Foundation of Australia and the Australian National Health and Medical Research Council (NHMRC grant number 216716). P. A. B. was the recipient of a European Society of Pediatric Infectious Diseases Fellowship Award and Melbourne International Research Scholarships from The University of Melbourne.