Reproducible selection of high avidity CD8( ) T-cell clones following secondary acute virus infection

Tania Cukalac; Jesseka Chadderton; Andreas Handel; Peter C Doherty; Stephen J Turner; Paul G Thomas; Nicole L La Gruta

Journal article

Reproducible selection of high avidity CD8( ) T-cell clones following secondary acute virus infection

Tania Cukalac, Jesseka Chadderton, Andreas Handel, Peter C Doherty, Stephen J Turner, Paul G Thomas, Nicole L La Gruta

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | NATL ACAD SCIENCES | Published : 2014

DOI: 10.1073/pnas.1323736111

University of Melbourne Researchers

Stephen Turner Author Microbiology and Immunology

Nicole La Gruta Author Microbiology and Immunology

Peter Doherty Author Microbiology and Immunology

Related Projects (2)

INVESTIGATING THE ROLE OF TCR AVIDITY IN INFLUENZA VIRUS-SPECIFIC CD8 T CELL RESPONSES

One of the constituents of the immune system is the cytotoxic, or killer, T cells and these are important in the overall protection from vir..

Determinants of CTL recruitment into the immune response

The size of CD8+ T cell (CTL) responses is central to their efficacy in virus control, and can be substantially influenced by how effectivel..

Grants

Awarded by National Health and Medical Research Council (NHMRC)

Awarded by National Institute of Health

Awarded by NHMRC Biomedical Postgraduate Scholarship

Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

Funding Acknowledgements

This work was supported by National Health and Medical Research Council (NHMRC) Project Grants AI628316 and AI1046333 (to N.L.L.G.), National Institute of Health Grants AI091938 (to P.G.T. and A.H.) and AI107625 (to P.G.T.), a Sylvia and Charles Viertel Senior Medical Research fellowship (to N.L.L.G.), an NHMRC Biomedical Postgraduate Scholarship ID520643 (to T.C.), and an Australian Research Council Future Fellowship (to S.J.T.).