Journal article
Predicting neurocognitive and behavioural outcome after early brain insult
VA Anderson, MM Spencer-Smith, L Coleman, PJ Anderson, M Greenham, R Jacobs, KJ Lee, RJ Leventer
Developmental Medicine and Child Neurology | Published : 2014
DOI: 10.1111/dmcn.12387
Abstract
Aims: The aims of the study were to investigate (1) the impact of age at brain insult on functional outcome and (2) the influence of insult and environmental factors on cognitive and behavioural outcomes. Method: The study was a cross-sectional, retrospective observational study, involving 138 children (76 males, 62 females; mean age 13y 1mo, SD 1y 11mo, range 10-16y) with magnetic resonance imaging (MRI) evidence of focal brain insult sustained from the first trimester of pregnancy to adolescence. Children underwent MRI and intellectual, executive, behavioural, and social evaluation. Outcome predictors were insult (lesion location, laterality, and extent, history of seizures, age at insult)..
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Funding Acknowledgements
Dr Anderson had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. This project was funded by a Linkage Grant from the Australian Research Council and by the Victorian Government Operational Infrastructure Scheme. The authors have stated that they had no interests that might be perceived as posing a conflict or bias.