How we mobilize haemopoietic stem cells
KE Herbert, J-P Levesque, AK Mills, DJ Gottlieb, J Cooney, J Szer, J Rasko, LB To
Internal Medicine Journal | WILEY | Published : 2011
Mobilization and collection of haemopoietic stem and progenitor cells (HSPC) is the cornerstone of autologous and allogeneic stem cell transplantation for a wide variety of haematological and some non-haematological malignancies. Centres providing this service face the challenge of optimizing the likelihood of successful collection of transplantable doses of cells, while maximizing the efficiency of the apheresis unit and minimizing the risk of toxicity as well as mobilization failure. Recent developments in the understanding of the molecular mechanisms of mobilization have led to the emergence of novel strategies for HSPC mobilization, which may assist in meeting these imperatives. The task..View full abstract
K. E. H. was funded by a Cancer Council of Victoria Early Career Clinician Researcher Grant. J.-P. L. was supported by a Senior Research Fellowship from the Cancer Council Queensland.