Induction of a Stringent Metabolic Response in Intracellular Stages of Leishmania mexicana Leads to Increased Dependence on Mitochondrial Metabolism

Eleanor C Saunders; William W Ng; Joachim Kloehn; Jennifer M Chambers; Milica Ng; Malcolm J McConville

Journal article

Induction of a Stringent Metabolic Response in Intracellular Stages of Leishmania mexicana Leads to Increased Dependence on Mitochondrial Metabolism

Eleanor C Saunders, William W Ng, Joachim Kloehn, Jennifer M Chambers, Milica Ng, Malcolm J McConville

PLOS PATHOGENS | PUBLIC LIBRARY SCIENCE | Published : 2014

DOI: 10.1371/journal.ppat.1003888

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University of Melbourne Researchers

Malcolm McConville Author Biochemistry and Molecular Biology

Eleanor Saunders Author Biochemistry and Molecular Biology

Milica Ng Author Bio21 Institute

Related Projects (1)

Metabolomic analysis of Leishmania

Leishmania are single-celled parasites that target a major class of immune cell, affecting millions and killing thousands of people worldwid..

Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

This work was supported by a Australian National Health and Medical Research Council (NHMRC) grant (APP1006023). WN was supported by an Australian Postgraduate Award. MJM is a NHMRC Principal Research Fellow (APP566643). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.