Surfactant before the first inflation at birth improves spatial distribution of ventilation and reduces lung injury in preterm lambs
David G Tingay, Megan J Wallace, Risha Bhatia, Georg M Schmoelzer, Valerie A Zahra, Melinda J Dolan, Stuart B Hooper, Peter G Davis
JOURNAL OF APPLIED PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2014
The interrelationship between the role of surfactant and a sustained inflation (SI) to aid ex utero transition of the preterm lung is unknown. We compared the effect of surfactant administered before and after an initial SI on gas exchange, lung mechanics, spatial distribution of ventilation, and lung injury in preterm lambs. Gestational-age lambs (127 days; 9 per group) received 100 mg/kg of a surfactant (Curosurf) either prior (Surf+SI) or 10 min after birth (SI+Surf). At birth, a 20-s, 35 cmH2O SI was applied, followed by 70 min of positive pressure ventilation. Oxygenation, carbon dioxide removal, respiratory system compliance, end-expiratory thoracic volume (via respiratory inductive pl..View full abstract
Awarded by National Health and Medical Research Council (NHMRC)
This study is supported by National Health and Medical Research Council (NHMRC) Project Grant 1009287 and by the Victorian Government Operational Infrastructure Support Program. D. Tingay is supported by NHMRC Clinical Research Fellowship Grant 1009287. P. Davis is supported by NHMRC Practitioner Fellowship Grant 556600 and Program Grant 556600. M. Wallace is supported by NHMRC Project Grant 1044775.