Journal article

Altered depth of the olfactory sulcus in ultra high-risk individuals and patients with psychotic disorders

Tsutomu Takahashi, Stephen J Wood, Alison R Yung, Barnaby Nelson, Ashleigh Lin, Murat Yuecel, Lisa J Phillips, Yumiko Nakamura, Michio Suzuki, Warrick J Brewer, Tina M Proffitt, Patrick D McGorry, Dennis Velakoulis, Christos Pantelis



A shallow olfactory sulcus has been reported in schizophrenia, possibly reflecting abnormal forebrain development during early gestation. However, it remains unclear whether this anomaly exists prior to the onset of psychosis and/or differs according to illness stage. In the current study, magnetic resonance imaging was used to investigate the length and depth of the olfactory sulcus in 135 ultra high-risk (UHR) individuals [of whom 52 later developed psychosis (UHR-P) and 83 did not (UHR-NP)], 162 patients with first-episode psychosis (FEP), 89 patients with chronic schizophrenia, and 87 healthy controls. While there was no group difference in the length of the sulcus, UHR-P subjects had si..

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Awarded by Japanese Society for the Promotion of Science

Awarded by NHMRC

Awarded by Grants-in-Aid for Scientific Research

Funding Acknowledgements

This research was supported in part by Grants-in-Aid for Scientific Research (C) (Nos. 22591275 and, 24591699) and Grants-in-Aid for Scientific Research (B) (No. 24390281) from the Japanese Society for the Promotion of Science, Health and Labour Sciences Research Grants (Comprehensive Research on Disability, Health and Welfare, H23-Seishin-Ippan-002 and H23-Seishin-Ippan-009), and Research Grants from the JSPS Asian Core Program and the Research Group For Schizophrenia, Japan. This research was also supported by NHMRC Program Grants (IDs: 350241, 566529). Professor Wood and Associate Professor Brewer were supported by Clinical Career Development Awards from the NHMRC, and A/Prof Brewer was additionally supported by the Colonial Foundation. Professor Yucel was supported by an NHMRC Senior Research Fellowship (ID: 1021973). Professor Pantelis was supported by an NHMRC Senior Principal Research Fellowship (ID: 628386) and a NARSAD Distinguished Investigator Award. The funding agencies had no further role in design and conduct of the study; collection, management, analysis and interpretation of the data; and preparation, review, or approval of the manuscript.