Journal article

n-3 PUFAs enhance the frequency of murine B-cell subsets and restore the impairment of antibody production to a T-independent antigen in obesity

Heather Teague, Cassie J Fhaner, Mitchel Harris, David M Duriancik, Gavin E Reid, Saame Raza Shaikh

JOURNAL OF LIPID RESEARCH | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2013

Abstract

The role of n-3 polyunsaturated fatty acids (PUFA) on in vivo B-cell immunity is unknown. We first investigated how n-3 PUFAs impacted in vivo B-cell phenotypes and antibody production in the absence and presence of antigen compared with a control diet. Lean mice consuming n-3 PUFAs for 4 weeks displayed increased percentage and frequency of splenic transitional 1 B cells. Upon stimulation with trinitrophenylated-lipopolysaccharide, n-3 PUFAs increased the number of splenic transitional 1/2, follicular, premarginal, and marginal zone B cells. n-3 PUFAs also increased surface, but not circulating, IgM. We next tested the effects of n-3 PUFAs in a model of obesity that is associated with suppr..

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University of Melbourne Researchers

Grants

Awarded by National Institutes of Health


Awarded by NATIONAL CENTER FOR COMPLEMENTARY &ALTERNATIVE MEDICINE


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES


Funding Acknowledgements

This work was supported by East Carolina Diabetes and Obesity Institute (EC-DOI) grants and by National Institutes of Health Grants R15 AT-006122 (to S.R.S.) and GM-103508 (to G.E.R.).