Journal article
Enhancing adoptive immunotherapy of cancer
JA Westwood, LJ Berry, LX Wang, CP Duong, HJ Pegram, PK Darcy, MH Kershaw
Expert Opinion on Biological Therapy | TAYLOR & FRANCIS LTD | Published : 2010
Abstract
Importance of the field: Conventional therapies, including surgery, chemotherapy and radiotherapy have contributed much to cancer treatment. However, these treatment modalities fail in a large proportion of patients, and there is a great need for effective alternate therapies. Adoptive immunotherapy can be effective against some cancers that have failed all other treatment options, even when disease burdens are massive. Areas covered in this review: This review gives a brief introduction of the historical origins of adoptive immunotherapy and then provides details of strategies for increasing the potency of cell transfer. Approaches for enhancing adoptive immunotherapy include: selecting the..
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Funding Acknowledgements
All support for authors was derived from the Australian governments and not-for-profit organizations: MH Kershaw was supported by a Senior Research Fellowship from the National Health and Medical Research Council of Australia NHMRC. PK Darcy was supported by a Career Development Award, from the NHMRC. JA Westwood was supported by the Bob Parker Memorial Foundation, and LJ Berry was supported by Susan G. Komen Breast Cancer Foundation.