Journal article

Galectin-7 acts as an adhesion molecule during implantation and increased expression is associated with miscarriage

EM Menkhorst, T Gamage, C Cuman, TJ Kaitu'u-Lino, S Tong, E Dimitriadis

PLACENTA | W B SAUNDERS CO LTD | Published : 2014

Abstract

INTRODUCTION: Galectins are expressed at the fetal-maternal interface and have multiple roles including during blastocyst implantation. The expression of galectin-7 however has not been investigated in the uterus. We aimed to localise galectin-7 to the endometrium of women with normal fertility and with a history of miscarriage and prospectively determine whether serum levels are altered in women who subsequently miscarry. We also investigated the role of galectin-7 on trophoblast-endometrial epithelial cell adhesion. METHODS: Immunohistochemistry localised galectin-7 to endometrium throughout the menstrual cycle in women (normal fertility or with history of miscarriage) and in first trimest..

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Grants

Awarded by NHMRC (Australia)


Funding Acknowledgements

This work was supported by NHMRC (Australia) Project/Program Grant (GNT1027100) to ED and EM, and by the Victorian Government's Operational Infrastructure Support Program. EM was supported by NHMRC (Australia) Early Career Fellowship (#611827). TKL was supported by NHMRC (Australia) New Investigator Project Grant (GNT1048707). ST was supported by an NHMRC (Australia) Career Development Fellowship (#1050765). ED was supported by NHMRC (Australia) Senior Research Fellowship (#550905).