Journal article
Active surveillance for adverse events following immunization
NW Crawford, H Clothier, K Hodgson, G Selvaraj, ML Easton, JP Buttery
Expert Review of Vaccines | Published : 2014
Abstract
Comprehensive surveillance of adverse events following immunization (AEFI) is required to detect potential serious adverse events that may not be identified in prelicensure vaccine trials. Surveillance systems have traditionally been passive, relying upon spontaneous reporting, but increasingly active surveillance and supplemental strategies are being incorporated into vaccine safety programs. These include active screening for targeted conditions of interest (e.g., hospitalization), monitoring of new data sources and real-time methodologies to detect changes in vaccine safety data in these sources. The role of improved causality assessment in AEFI surveillance is discussed, with its importa..
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Awarded by Centers for Disease Control and Prevention
Funding Acknowledgements
NW Crawford and JP Buttery have acted as chief investigators for epidemiological studies sponsored by vaccine manufacturers (CSL) and serological testing (Merck). All payments, including for sitting on advisory boards (NW Crawford), data safety monitoring boards (JP Buttery), lecturing (NW Crawford) and travel expenses for attendance at scientific meetings, are paid directly to an administrative fund held by Murdoch Children's Research Institute. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.