Journal article

Breast Implant-Associated Anaplastic Large-Cell Lymphoma: Long-Term Follow-Up of 60 Patients

Roberto N Miranda, Tariq N Aladily, H Miles Prince, Rashmi Kanagal-Shamanna, Daphne de Jong, Luis E Fayad, Mitual B Amin, Nisreen Haideri, Govind Bhagat, Glen S Brooks, David A Shifrin, Dennis P O'Malley, Chan Y Cheah, Carlos E Bacchi, Gabriela Gualco, Shiyong Li, John A Keech, Ephram P Hochberg, Matthew J Carty, Summer E Hanson Show all

JOURNAL OF CLINICAL ONCOLOGY | AMER SOC CLINICAL ONCOLOGY | Published : 2014

Abstract

PURPOSE: Breast implant-associated anaplastic large-cell lymphoma (ALCL) is a recently described clinicopathologic entity that usually presents as an effusion-associated fibrous capsule surrounding an implant. Less frequently, it presents as a mass. The natural history of this disease and long-term outcomes are unknown. PATIENTS AND METHODS: We reviewed the literature for all published cases of breast implant-associated ALCL from 1997 to December 2012 and contacted corresponding authors to update clinical follow-up. RESULTS: The median overall survival (OS) for 60 patients was 12 years (median follow-up, 2 years; range, 0-14 years). Capsulectomy and implant removal was performed on 56 of 60 ..

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