Paramutation-Like Interaction of T-DNA Loci in Arabidopsis
Weiya Xue, Colin Ruprecht, Nathaniel Street, Kian Hematy, Christine Chang, Wolf B Frommer, Staffan Persson, Totte Niittyla
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2012
In paramutation, epigenetic information is transferred from one allele to another to create a gene expression state which is stably inherited over generations. Typically, paramutation describes a phenomenon where one allele of a gene down-regulates the expression of another allele. Paramutation has been described in several eukaryotes and is best understood in plants. Here we describe an unexpected paramutation-like trans SALK T-DNA interaction in Arabidopsis. Unlike most of the previously described paramutations, which led to gene silencing, the trans SALK T-DNA interaction caused an increase in the transcript levels of the endogenous gene (COBRA) where the T-DNA was inserted. This increase..View full abstract
This work was supported by grants from the Swedish research agency FORMAS, the Human Frontier Science Program and Bio4Energy, the Swedish Programme for renewable energy. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.