Journal article
Higher plant calreticulins have acquired specialized functions in arabidopsis
A Christensen, K Svensson, L Thelin, W Zhang, N Tintor, D Prins, N Funke, M Michalak, P Schulze-Lefert, Y Saijo, M Sommarin, S Widell, S Persson
Plos One | Published : 2010
Open access
Abstract
Background: Calreticulin (CRT) is a ubiquitous ER protein involved in multiple cellular processes in animals, such as protein folding and calcium homeostasis. Like in animals, plants have evolved divergent CRTs, but their physiological functions are less understood. Arabidopsis contains three CRT proteins, where the two CRTs AtCRT1a and CRT1b represent one subgroup, and AtCRT3 a divergent member. Methodology/Principal Findings: Through expression of single Arabidopsis family members in CRT-deficient mouse fibroblasts we show that both subgroups have retained basic CRT functions, including ER Ca2+-holding potential and putative chaperone capabilities. However, other more general cellular defe..
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Awarded by Canadian Institute of Health Research
Funding Acknowledgements
NF and SP were funded through the Max-Planck Gesellschaft. MM is supported by the Canadian Institute of Health Research (MOP-15291), and DP was supported by an Alberta Heritage for Medical Research Summer Student Award. MS was supported by the Swedish Research Council, Swedish Foundation for Strategic Research, and The Swedish Research Council Formas. SW was supported by the Carl Tryggers Foundation. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.