Journal article
In vivo measurement of hippocampal GABAa/cBZR density with [18F]-flumazenil PET for the study of disease progression in an animal model of temporal lobe epilepsy
L Vivash, MC Gregoire, V Bouilleret, A Berard, C Wimberley, D Binns, P Roselt, A Katsifis, DE Myers, RJ Hicks, TJ O'Brien, S Dedeurwaerdere
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2014
Abstract
Purpose: Imbalance of inhibitory GABAergic neurotransmission has been proposed to play a role in the pathogenesis of temporal lobe epilepsy (TLE). This study aimed to investigate whether [18F]-flumazenil ([ 18F]-FMZ) PET could be used to non-invasively characterise GABA A/central benzodiazepine receptor (GABAA/cBZR) density and affinity in vivo in the post-kainic acid status epilepticus (SE) model of TLE. Methods: Dynamic [18F]-FMZ -PET scans using a multi-injection protocol were acquired in four male wistar rats for validation of the partial saturation model (PSM). SE was induced in eight male Wistar rats (10 weeks of age) by i.p. injection of kainic acid (7.5-25 mg/kg), while control rats ..
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Funding Acknowledgements
This study was funded by the cooperative research consortium for biomedical imaging development (CRC-BID). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.