Journal article
An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4 T cells from aviremic patients.
CA Spina, J Anderson, NM Archin, A Bosque, J Chan, M Famiglietti, WC Greene, A Kashuba, SR Lewin, DM Margolis, M Mau, D Ruelas, S Saleh, K Shirakawa, RF Siliciano, A Singhania, PC Soto, VH Terry, E Verdin, C Woelk Show all
PLoS pathogens | PUBLIC LIBRARY SCIENCE | Published : 2013
Abstract
The possibility of HIV-1 eradication has been limited by the existence of latently infected cellular reservoirs. Studies to examine control of HIV latency and potential reactivation have been hindered by the small numbers of latently infected cells found in vivo. Major conceptual leaps have been facilitated by the use of latently infected T cell lines and primary cells. However, notable differences exist among cell model systems. Furthermore, screening efforts in specific cell models have identified drug candidates for "anti-latency" therapy, which often fail to reactivate HIV uniformly across different models. Therefore, the activity of a given drug candidate, demonstrated in a particular c..
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Awarded by U.S. Department of Veterans Affairs
Funding Acknowledgements
This work was supported by the Collaboratory of AIDS Researchers for Eradication (NIH Grant U19AI096113; DMM, Principal Investigator; CAS, WCG, RFS, EV, CW, VP Project Leaders). This work was performed with the support of the Genomics and Flow Cytometry Cores at the UCSD Center for AIDS Research (AI36214), the San Diego Veterans Medical Research Foundation, and The James B. Pendleton Charitable Trust. This material is based upon work supported in part by the Department of Veterans Affairs (VA), Veterans Health Administration, Office of Research and Development. SRL is supported by the National Health and Medical Research Council (NHMRC) of Australia (APP1042654, APP1041795, APP1002761, APP1009533) and the National Institutes of Health (1R56AI095073-01A1) and the Delaney AIDS Research Enterprise (DARE) to find a cure collaboratory (U19 AI096109), the Danish Medical Council and the University of Malaya. SRL is an NHMRC Practitioner Fellow. SRL gratefully acknowledges the contribution to this work of the Victorian Operational Infrastructure Support Program received by the Burnet Institute. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.