Journal article
Among vitamin B12 deficient older people, high folate levels are associated with worse cognitive function: Combined data from three cohorts
EM Moore, D Ames, AG Mander, RP Carne, H Brodaty, MC Woodward, K Boundy, KA Ellis, AI Bush, NG Faux, RN Martins, CL Masters, CC Rowe, C Szoeke, DA Watters
Journal of Alzheimer S Disease | IOS PRESS | Published : 2014
DOI: 10.3233/JAD-131265
Abstract
Background: Folate fortification of food aims to reduce the number of babies born with neural tube defects, but has been associated with cognitive impairment when vitamin B12 levels are deficient. Given the prevalence of low vitamin B12 levels among the elderly, and the global deployment of food fortification programs, investigation of the associations between cognitive impairment, vitamin B12, and folate are needed. Objective: To investigate the associations of serum vitamin B12, red cell folate, and cognitive impairment. Methods: Data were collected on 1,354 subjects in two studies investigating cognitive impairment, and from patients attending for assessment or management of memory proble..
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Funding Acknowledgements
[ "The PRIME study was funded by Janssen Australia. The investigators thank the participants and clinicians at all nine sites who contributed to collection of the data: Prince of Wales Hospital (Marika Donkin, Kim Burns, Katrin Seeher); The Queen Elizabeth Hospital (Shelley Casey, Trish Steventon); St George's Hospital (Maree Mastwyk, Alissa Westphal, Nicola Lautenschlager, Olga Yastrubetskaya, Marilyn Kemp, Edmond Chiu and Jennifer Ames); Austin Health Repatriation Hospital (Irene Tan, Henry Zeimer, Leonie Johnston); Hornsby Ku-Ring-Gai Hospital (Sue Kurrle, Roseanne Hogarth, Judith Allan); Fremantle Hospital (Roger Clarnette, Janice Guy, Denae Clark); The Prince Charles Hospital (Chris Davis, Mary Wyatt, Katrina Brosnan, Margaret Morton); Rankin Park Hospital (John Ward, Jeanette Gatgens); Geelong Private Hospital (Bernadine Charles).", "Core funding for the AIBL study was provided by CSIRO which was supplemented by \"in kind\" contributions from the study partners: The University of Melbourne, Neurosciences Australia Ltd (NSA), Edith Cowan University (ECU), Mental Health Research Institute (MHRI), Alzheimer's Australia (AA), National Ageing Research Institute (NARI), Austin Health, University of Western Australia (UWA), CogState Ltd, Macquarie University, Hollywood Private Hospital, Sir Charles Gardner Hospital. Alzheimer's Australia (Victoria and Western Australia) assisted with promotion of the study and screening of telephone calls from volunteers. The AIBL study currently receives funding from the Science Industry Endowment fund." ]