Journal article

Synthesis and characterization of biocompatible nanodiamond-silk hybrid material

Asma Khalid, Rebecca Lodin, Peter Domachuk, Hu Tao, Jodie E Moreau, David L Kaplan, Fiorenzo G Omenetto, Brant C Gibson, Snjezana Tomljenovic-Hanic

BIOMEDICAL OPTICS EXPRESS | OPTICAL SOC AMER | Published : 2014

Abstract

A new hybrid material consisting of nanodiamonds (NDs) and silk has been synthesized and investigated. NDs can contain bright fluorescence centers, important for bioprobes to image biological structures at the nanoscale and silk provides a transparent, robust matrix for these nanoparticles in-vivo or in-vitro. The ND-silk hybrid films were determined to be highly transparent in the visible to near infrared wavelength range. The NDs embedded in silk exhibited significant enhancement of emission relative to air, correlating with theoretical predictions. Furthermore, animal toxicity tests confirmed ND-silk films to be non-toxic in an in-vivo mice model.

Grants

Awarded by ARC Australian Postdoctoral Fellowship


Awarded by ARC Future Fellowship


Awarded by ARC Australian Research Fellowship


Funding Acknowledgements

P.D. sadly deceased in January 2013, he was supported by an ARC Australian Postdoctoral Fellowship (DP1096831). B.C.G. is supported by an ARC Future Fellowship (FT110100225). S.T- H. is supported by an ARC Australian Research Fellowship (DP1096288).