Journal article

KRAS mutations in ovarian low-grade endometrioid adenocarcinoma: association with concurrent endometriosis

Colin JR Stewart, Yee Leung, Michael D Walsh, Rhiannon J Walters, Joanne P Young, Daniel D Buchanan

HUMAN PATHOLOGY | W B SAUNDERS CO-ELSEVIER INC | Published : 2012

Abstract

The association between ovarian endometrioid adenocarcinoma and endometriosis is well established. However, not all endometrioid adenocarcinomas are directly related to endometriosis, and it has been suggested that there may be clinicopathologic differences between endometriosis-positive and endometriosis-negative tumors. Molecular alterations in endometrioid adenocarcinoma include KRAS and BRAF mutations, but the incidence of these abnormalities in previous reports has been highly variable (0%-36% and 0%-24%, respectively). This may be explained by relatively small sample sizes in earlier studies but could also reflect difficulties in accurately classifying high-grade ovarian malignancies. ..

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University of Melbourne Researchers